{
  "status": "PASS",
  "analysis_date": "2026-08-13",
  "sampling_unit": "separately sampled repeated-cross-sectional specimen rows",
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  "cage_id_available": false,
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    "exposure_anchor_Pstar": "(ZMF_E8-GMF_E8)-B",
    "recovery_residual_Qstar": "(ZMF_R-GMF_R)-B",
    "recovery_step_S": "Qstar-Pstar",
    "direction_anchor": "Pstar and Qstar",
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    "ZMF_R": "GMF"
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  "zt_labels": [0, 6, 12, 18, 24],
  "cosinor_unique_phases": [0, 6, 12, 18],
  "period_hours": 24,
  "rhythm_model": "fixed-effect population cosinor with sex covariate",
  "rhythm_test": "HC3 joint Wald test of sine and cosine, 2 df",
  "primary_bh_q": 0.05,
  "microbiome_preprocessing": {
    "low_count_to_zero_below": 4,
    "minimum_prevalence": 0.2,
    "minimum_tss_variance_quantile": 0.5,
    "transform": "sample-wise zero replacement then CLR"
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  "metabolomics_preprocessing": {
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    "sensitivity_qc_cv_max": 0.2,
    "transform": "log2 supplier-normalized positive intensity",
    "formal_unit": "unique Type/MZ/RT intensity profile"
  },
  "rna_scope": "E8 context only; no recovery inference",
  "synthesis": {
    "validation": "analysis/18_full_reanalysis/synthesis/validation.json",
    "validation_sha256": "cbb3a6909d1f4212eed15f0547f36ecd05cd68842143f8c7c7227e3da7d27890",
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    "checks_passed": "28/28"
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  "separate_validated_report_deployment_authorized": true
}